In Manhattan, the vampires Goody and Stacy share an apartment. Goody was turned in vampire in 1840 by the evil Cisserus, who also turned Stacy in the 90s, and they became best friends. They only drink mice blood and refuse to drink human blood.

Stacy falls in love with her classmate Joey, and soon she learns that he is the son of the vampire slayer Dr. Van Helsing.

Meanwhile, Goody meets her former passion, Danny, in the hospital where his wife is terminal. When Stacy gets pregnant, Goody knows that the only way that the child can survive is killing Cisserus, since they would revert to their human ages. But nobody knows here her lair is.